Skopje is the capital and largest city of the Republic of Macedonia. It is the country's political, cultural, economic, and academic center. Skopje is located on the upper course of the Vardar River, and is located on a major north-south Balkan route between Belgrade and Athens. It was known in the Roman period under the name Scupi.

The territory of Skopje has been inhabited since at least 4000 BC; remains of Neolithic settlements have been found within the old Kale Fortress that overlooks the modern city centre. On the eve of the 1st century AD, the settlement was seized by the Romans and became a military camp. When the Roman Empire was divided into eastern and western halves in 395 AD, Scupi came under Byzantine rule from Constantinople.

Being the capital of the Republic of Macedonia, Skopje is home to the largest cultural institutions of the country, such as the National and University Library "St. Kliment of Ohrid", the Macedonian Academy of Sciences and Arts, the National Theatre, the National Philarmonic Orchestra and the Macedonian Opera and Ballet. Among the local institutions are the Brothers Miladinov Library which has more than a million documents, the Cultural Information Centre which manages festivals, exhibitions and concerts, and the House of Culture Kočo Racin which is dedicated to contemporary art and young talents.

The Skopje Jazz Festival has been held annually in October since 1981. It is part of the European Jazz Network and the European Forum of World Wide Festivals. The artists' profiles include fusion, acid jazz, Latin jazz, smooth jazz, and avant-garde jazz. Ray Charles, Tito Puente, Gotan Project, Al Di Meola, Youssou N'Dour, among others, have performed at the festival. Another music festival in Skopje is the Blues and Soul Festival. It is a relatively new event in the Macedonian cultural scene that occurs every summer in early July. Past guests include Larry Coryell, Mick Taylor & the All-Stars Blues Band, Candy Dulfer & Funky Stuff, João Bosco, The Temptations, Tolo Marton Trio, Blues Wire, and Phil Guy.

Vranje is a city and the administrative center of the Pčinja District in southern Serbia. The city has a population of 83,524 inhabitants, while the urban area of the city has 60,485 inhabitants.

Vranje is the first city from the Balkans to be declared UNESCO city of Music. It is on located on the Pan-European Corridor X, close to the borders with North Macedonia and Bulgaria. The Eparchy of Vranje is seated in the city and the 4th Land Force Brigade of the Serbian army is stationed here.

Vranje was an important Ottoman trading site. The White Bridge is a symbol of the city and is called "most ljubavi" (lovers' bridge) after the tale of the forbidden love between the Muslim girl Ajša and Christian Stojan that resulted in the father killing the couple. After that, he built the bridge where he had killed her and had the story inscribed in Ottoman Arabic. The city has traditional Balkan and Ottoman architecture.

The well-known theater play Koštana by Bora Stanković is set in Vranje.

Vranje is famous for its popular, old music, lively and melancholic at the same time. The best known music is from the theater piece with music, Koštana, by Bora Stanković. This original music style has been renewed recently by taking different, specific, and more oriental form, with the contribution of rich brass instruments. It is played particularly by the Vranje Romani people.

Vranje lies close to Besna Kobila mountain and Vranjska Banja, locations with high potential that are underdeveloped. Other locations in and around Vranje with some tourist potential include Prohor Pčinjski monastery, Kale-Krševica, Markovo kale, Pržar, birth-house museum of Bora Stankovic.