Loznica is a city located in the Mačva District of the western Serbia. It lies on the right bank of the Drina river. Its name stems from the word "loza" (the Serbian word for vine). Originally, its name was Lozica (Serbian for small vine), but it later became Loznica.

Loznica has a humid subtropical climate with cold winters, often very cold due to the mountain winds of nearby mountains, and warm to hot summers. When hot air from Adriatic Sea starts going inland, to the north-east it rises over mountain barriers (Zlatar and Zlatibor), gaining jet effect and continuing fast to western parts of Serbia.

Among cultural heritage include the Church of the Holy Virgin located in the town, the 14th-century Čokešina Monastery, the 13th-century Tronoša Monastery, and monuments on Mount Gučevo, in Tekeriš, and in Draginac, as well as the ethnic village of Tršić.

A Serbian epic poem is the Battle of Loznica in which the central figure Anta Bogičević leads Serbian forces during the First Serbian Uprising. The most important local cultural event is "Vukov Sabor" (Council of Vuk) in Tršić, held annually in September, in memory of Vuk Stefanović Karadžić who was born in the village; it remains the oldest and largest cultural event in Serbia, for its importance and the increasing volume (20-30,000 visitors).