Prilep is the fourth largest city in North Macedonia. It has a population of 66,246 and is known as "the city under Marko's Towers" because of its proximity to the towers of Prince Marko.

The name of the city comes from the Macedonian word "Прилеп" (meaning "sticky") and it showcases how the buildings were first built there, being near one another next to the Marko's Towers.

The main square in Prilep is called "Alexandria", in honor of Alexander the Great. The reconstruction of the square began in 2005 and it was completed in 2006. The reconstruction cost 700.000 Euros and its investor was the city of Prilep. During the reconstruction the monument of Alexander the Great was erected, among the other things.

The most important ancient monument is the old city of Styberra situated on Bedem hill near Čepigovo, in the central region of Pelagonia. As early as the time of the Roman–Macedonian wars, this city was known as a base from which the Macedonian king Perseus of Macedon set out to conquer the Penestian cities. An important site in the area is Bela Crkva, 6 km (4 mi) west of Styberra, where the town of Alkomenai was probably located. It was a stronghold of the Macedonian kings after it was rebuilt in the early Roman period and was at the Pelagonian entrance to a pass leading to Illyria. Part of the city wall, a gate, and a few buildings of the Roman period were uncovered here in excavations. All recent finds from these sites are in the Museum of the City of Prilep.

Resen is a town in southwestern North Macedonia, with just under 9,000 inhabitants. Resen is approximately equidistant between Bitola and Ohrid. The town rises 880 metres (2,887 feet) above sea level and is situated near Lake Prespa. Resen is also the only town in the Prespa Lake area and is the seat of Resen Municipality.

Resen has a mild continental climate with cold winters and warm summers, which makes it a tourist attraction, especially in summer. The climate and the quality of soil are key factors for Prespa's region to have a long tradition of agriculture. One of most important landmarks of Resen's today are the apple orchards, well known for the quality and specific taste of apples.

Resen is home to Prespa's Ceramic Colony, established in the 1970s, which attracts renowned artists from all over the world. The organization is included in the UNESCO International Academy of Ceramics. It is housed in the Saraj, which also houses the Dragi Tozija House of Culture, the Keraca Visulčeva Gallery, and a library.