Štip is the largest urban agglomeration in the eastern part of North Macedonia, serving as the economic, industrial, entertainment and educational focal point for the surrounding municipalities.

As of the 2002 census, the Štip municipality alone had a population of about 47,796.

Štip is the largest textile production center in the country; Center of the fashion industry in North Macedonia, as well as the location of the sole public university in eastern North Macedonia, Goce Delčev University of Štip.

Štip boasts the largest festival of pop music in North Macedonia, called MakFest. It has been held every November in the cultural center, "Aco Šopov", for over two decades.

Another large cultural event in Štip is the "Štip Summer of Culture" (Macedonian: Штипско Културно Лето), which is a monthlong festival held from 1 July to 1 August, since 1987. The first known opera performance in North Macedonia was staged in Štip in 1925.

Bitola is a city in the southwestern part of North Macedonia. It is located in the southern part of the Pelagonia valley, surrounded by the Baba, Nidže and Kajmakčalan mountain ranges, 14 kilometres north of the Medžitlija-Níki border crossing with Greece. The city stands at an important junction connecting the south of the Adriatic Sea region with the Aegean Sea and Central Europe, and is an administrative, cultural, industrial, commercial, and educational centre. It has been known since the Ottoman period as "The City of The Consuls", since many European countries had consulates in Bitola.

Bitola, known during the Ottoman Empire as Manastir/Monastir, is one of the oldest cities in North Macedonia. It was founded as Heraclea Lyncestis in the middle of the 4th century BC by Philip II of Macedon. The city was the last capital of Ottoman Rumelia, from 1836 to 1867. According to the 2002 census, Bitola is the second-largest city in the country.

Bitola is the economic and industrial center of southwestern North Macedonia. Many of the largest companies in the country are based in the city. The Pelagonia agricultural combine is the largest producer of food in the country. The Streževo water system is the largest in North Macedonia and has the best technological facilities. The three thermoelectric power stations of REK Bitola produce nearly 80% of electricity in the state. The Frinko refrigerate factory was a leading electrical and metal company. Bitola also has significant capacity in the textile and food industries.

Bitola has been part of the UNESCO Creative Cities Network since December 2015.